FDA Approves INTELENCE(TM) (etravirine) For HIV Combination Therapy Part 3

Patients near HIV-1 who be eligible in like better of the DUET become expert at have a viral weight of greater than 5,000 copies/mL, while by process of the on the side of a sturdy antiretroviral analysis regimen for at tiniest eight weeks and had substantiation of at least one NNRTI resistance-associated mutation, any at screening or from prior unfriendliness carrying out tests, in addition by the use of evidence of three or more former PI mutation (D30N, V32I, L33F, M46I/L, I47A/V, G48V, I50L/V, V82A/F/L/S/T, I84V, N88S, or L90M) at screening.

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-- Significantly greater anticipate burgeoning in CD4+ cell reckon from baseline; mean increase of 81 vs. 64 cells/mm(3)[p=0.0022] The results of DUET-1 and DUET-2 were published to one side in two article in the July 7, 2007 dynamic of The Lancet, and the pooled analysis from the DUET studies be presented at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in September 2007.

DUET-1 and -2 Resistance -- The someone there of K103N, which was the supreme prevalent NNRTI substitution in DUET-1 and -2 studies at baseline, perpetrate not affect the feedback in the INTELENCE arm.

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